OHRPP IRB Submissions

The Office of Human Research Protection Programs supports two internet-based software applications to support the submission, review, and approval of research projects involving human subjects:

1.  webIRB 
   
   1. Amendment/Continuing Review-Closure/ PARs for active and previously approved submissions in webIRB that have not been migrated to BruinIRB.
2. BruinIRB
   
   1. All new studies must be submitted in BruinIRB as of September 9, 2025.  See BruinIRB Deployment FAQs for more information.
   2. If you have received a notice that your approved webIRB study has been migrated to BruinIRB, all future amendments, continuing reviews and PARs must be submitted in BruinIRB.  

Please forward any questions or concerns to BruinIRB@research.ucla.edu or consult the BruinIRB Resource Library for quick guides, training videos, and other information.

*Effective January 25, 2023, all NEW Industry-sponsored, multi-site FDA-regulated research conducted at UCLA must use a single IRB, per the June 2023, UCLA Policy Board (HRPB) determination.  Accordingly, investigators must identify an external IRB (e.g. Advarra or WCG) that will serve as Reviewing IRB for these research studies.  Investigators must submit a request to cede review to an external IRB in BRUIN IRB.

Both applications are designed to branch in response to information provided about the study procedures. Each system requires an account that uses the single sign-on UCLA Logon ID credentials. Both applications function as a document repository, providing study personnel with easy access to study documents like approved consent forms.

NOTE:
Submission requirements for amendments, continuing review, and post-approval monitoring reports will differ for studies approved by an external IRB, including clinical studies approved by a commercial IRB.  Review the IRB Reliance Policy and the FAQs for the Commercial IRB Review  for additional information.

• All users must have a webIRB account to log into webIRB. Please visit the “How to get a webIRB account” page for instructions.
• Access BruinIRB Accounts page for instructions on how to request an account for BruinIRB.

For general questions, contact the OHRPP's main phone numbers (310) 825-5344 for the Medical IRB or (310) 825-7122 for the General Campus IRB. For questions specific to the webIRB application, email webIRBHelp@research.ucla.edu. Questions related to BruinIRB should be directed to BruinIRB@research.ucla.edu. Please be sure to describe the nature of your question.